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How Cannabis Works

Biochemistry

The active ingredients in Cannabis – cannabinoids and terpenes – are delivered to the blood through the lungs (when inhaled), the digestive system (when consumed) or the skin (when applied topically). From the blood, they are available to the brain, central nervous system and immune system.

Humans are built to inter – act with cannabinoids, with endocannabinoid systems of special receptor molecules embedded in our brains and along neural pathways. The receptors influence the flow of chemical signals to the brain.

Cannabinoids bind with the endocannabinoid receptors, creating medicinal effects by suppressing signals such as pain, nausea and depres – sion while boosting signals of appetite and euphoria.

Areas of Brain with High Concentrations of Cannabinoid Receptors

References

  • Bergamaschi M.M., Queiroz R.H., Zuardi A.W., Crippa J.A. Safety and side effects of cannabidiol, a Cannabis sativa constituent.Curr Drug Saf. 2011 Sep 1; 6(4):237-49.
  • Carter GT1, Weydt P, Kyashna-Tocha M, Abrams DI. Medicinal cannabis: rational guidelines for dosing. IDrugs. 2004 May; 7(5):464-70.
  • Grotenhermen Franjo. 2003. Clinical Pharmacokinetics of Pharmacodynamics of Cannabinoids. Clinical Pharmacokinetics. 42(4): 327-60.
  • Russo E., Guy G.W. A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. Medical Hypotheses. 2006; 66(2):234-246.

THC & CBD Products Now Available

Curaleaf offers a range of safe, legal, low-THC and full-strength cannabis products made using the industry’s cleanest, most medically precise extraction and purification methods

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